Compromised redox homeostasis, altered nitroso–redox balance, and therapeutic possibilities in atrial fibrillation
نویسندگان
چکیده
منابع مشابه
Monoamine Oxidase is a Major Determinant of Redox Balance in Human Atrial Myocardium and is Associated With Postoperative Atrial Fibrillation
BACKGROUND Onset of postoperative atrial fibrillation (POAF) is a common and costly complication of heart surgery despite major improvements in surgical technique and quality of patient care. The etiology of POAF, and the ability of clinicians to identify and therapeutically target high-risk patients, remains elusive. METHODS AND RESULTS Myocardial tissue dissected from right atrial appendage...
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When new therapy challenges a critical disease the clinical spectrum is changed. But although the implantable cardioverter defibrillator is at the forefront of ventricular arrhythmia treatment, the number of implantations per million population remains limited (Fig. 1). The reasons for this poor take up must be one of costs set against the benefits, and indeed, the implantable cardioverter defi...
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Methods and results A prospective observational study including 553 non-valvular AF patients. Time in therapeutic range was calculated for all patients treated with VKAs, and adherence to Med-Diet was evaluated with a validated nine-item dietary questionnaire. Cardiovascular events (CVEs), such as cardiovascular death and fatal/non-fatal stroke or myocardial infarction, and bleedings were recor...
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Maintenance of atrial fibrillation is a complex mechanism, including extensive electrical and structural remodeling of the atria which involves progressive fibrogenesis. Galectin-3 is a biomarker of fibrosis, and, thus, may be involved in atrial remodeling in atrial fibrillation patients. We review the role of galectin-3 in AF mechanisms and its potential therapeutic implications.
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from altered intrinsic SAN pacemaker function. Indeed, spontaneous action potential frequencies in SAN myocytes with CIO were reduced in association with decreased L-type Ca current (ICa,L) densities and positive (rightward) voltage shifts in ICa,L activation. Pacemaker current (If) was not affected by CIO. Because ICa,L in SAN myocytes (as well as in atrial and conducting system myocytes) acti...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2016
ISSN: 0008-6363,1755-3245
DOI: 10.1093/cvr/cvw012